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| Registros recuperados: 3.453 | |
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| Helena Deus. |
| Cancer is still one of the leading causes of death in the developed world. To address this problem, the US National Institutes of Health (NIH) has launched The Cancer Genome Atlas (TCGA), a large scale systematic approach to characterize tumor samples from 20 cancer types and approximately 10,000 donor patients by using multiple high-throughput approaches. 

Multidisciplinary projects such as TCGA and related projects across Europe aim at identifying cancer “driver” mutations to be used as therapeutic targets or diagnostic tests. Extracting and aggregating the knowledge necessary to identify such mutations remains a challenge primarily due to the need to reliably integrate the experimental datasets... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6169/version/1 |
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| BaoDe Chen; WeiYi Xu; Chen Yu; ZhenYun Ni; XueFen Li; DaWei Cui. |
| Background: Obesity promotes progression to microalbuminuria and increases the risk of chronic kidney disease. Current protocols of screening microalbuminuria are not recommended for the overweight or obese.

Design and Methods: A cross-sectional study was conducted. The relationship between metabolic risk factors and microalbuminuria was investigated. A regression model based on metabolic risk factors was developed and evaluated for predicting microalbuminuria in the overweight or obese.

Results: The prevalence of MA reached up to 17.6% in Chinese overweight men. Obesity, hypertension, hyperglycemia and hyperuricemia were the important risk factors for... |
| Tipo: Manuscript |
Palavras-chave: Molecular Cell Biology; Evolutionary Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5372/version/1 |
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| Sierra Rayne; Kaya Forest. |
| A long-term analysis of temporal trends and frequency analyses for temperatures (1913-2010), precipitation (1909-2010), and wind speed (1954-1996) was conducted on the Moose Jaw climate station in south-central Saskatchewan, Canada. Average annual and springtime temperatures are increasing over time, as are daily mean temperatures during March. Mean daily maximum temperatures are increasing on an annual basis and during the spring period, whereas mean daily minimum temperatures are increasing during February, March, August, and September, as well as on an annual basis and during spring and summer. There are significant positive time trends for growing degree days base 8C (GDD~8~) and 10C (GDD~10~). Rainfall has been increasing during March as well as... |
| Tipo: Poster |
Palavras-chave: Earth & Environment. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6703/version/1 |
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| Xiaolin Zhang. |
| The neuron, when considered as a signal processing device, itsinputs are the frequency of pulses received at the synapses, and its output is the frequency of action potentials generated- in essence, a neuron is a pulse frequency signal processing device. In comparison, electrical devices use either digital or analog signals for communication or processing, and the mathematics behind these subjects is well understood. However, in regards to pulse frequency processing devices, there has not yet been a clear and persuasive mathematical model to describe the functions of neurons. It goes without saying that such a model is very important, not only for understanding neuron and neural system behavior, but also for undeveloped potential applications in industry.... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1703/version/1 |
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| Saaniya Contractor; Nataliya Kozlova; Vladimir Brezina. |
| For a sensorimotor network to generate adaptive behavior in the environment, the phases of the behavior must be appropriately timed. When the behavior is driven simply by the sensory stimuli from the environment, these can supply the timing. But when the behavior is driven by an internal "goal" that ignores and perhaps even opposes the immediate sensory stimuli, the timing must be generated internally by the network. We have modeled a realistic behavioral scenario that requires such internal timing.

When the sea slug Aplysia feeds, it incrementally ingests long strips of seaweed, driven by ingestive stimuli emanating from the seaweed. But if, having ingested a strip, the animal fails to break the... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2817/version/1 |
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| Daniel R. Taub. |
| I performed a meta-analysis of studies examining the relationships among nutrient availability, plant growth rate and allocation to roots vs. shoots. Species characteristic of high fertility habits grew faster than species characteristic of less fertile habitats. While species were highly plastic in root/shoot ratio, there was a strong correlation in root/shoot across fertility levels when plants were grown across fertility gradients. This suggests that the proportional mass allocation to roots is a consistent characteristic of individual species relative to other species. There was no consistent relationship between allocation to roots and either growth rate or the fertility of habitats that species typically are found in. |
| Tipo: Manuscript |
Palavras-chave: Ecology; Plant Biology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/185/version/1 |
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| Saheeb Ahmed Kayani. |
| In this research report, X-ray diffraction (XRD) and X-ray fluorescence (XRF) spectrometry have been used to determine the mineralogical and elemental composition of a stone sample recovered from a location near village Lehri in district Jhelum, Pakistan. The test data is compared with previous findings (as reported in literature and included in references) to identify this sample stone as part of a prehistoric meteorite ablation debris.
Further to this, carbon content of a specimen of the meteorite debris has been determined through combustion analysis. This carbon abundance has been compared with carbon wt% value of a certain type of meteorites to establish the origin and nature of the parent body of this particular meteorite debris. |
| Tipo: Manuscript |
Palavras-chave: Chemistry; Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5450/version/1 |
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| Dawid Mazurek. |
| Although the colonialism surely developed independently in Graptolithoidea and Bryozoa, both groups share similar patterns of astogeny. One of the common features is the presence of morphological gradients. Many attempts at its explanation were made for more than a half of the century. This paper discusses a new model of the late astogeny in some bryozoan colonies, showing a cyclic reappearance of secondary zones of astogenetic change and astogenetic repetition that cannot be explained by the single morphogen gradient theory. |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1585/version/1 |
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| Xin Zou; Damien Coyle; KongFatt Wong-Lin; Liam Maguire. |
| Many dementia cases, such as Alzheimer’s disease (AD), are characterized by an increase in low frequency field potential oscillations. However, a definitive understanding of the effects of the beta-Amyloid peptide, which is a main marker of AD, on the low frequency theta rhythm (4-7Hz) is still unavailable. In this work, we investigate the neural mechanisms associated with beta-Amyloid toxicity using a conductance-based neuronal network model of the hippocampus CA1 region. We simulate the effects of beta-Amyloid on the A-type fast inactivating K+ channel by modulating the maximum conductance of the current in pyramidal cells, denoted by gA. Our simulation results demonstrate that as gA decreases (through A[beta]
blockage), the... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6004/version/1 |
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| Michael T. Cooling. |
| In the last decade or so, model encoding efforts such as CellML and SBML have greatly facilitated model availability. But, as the complexity of models increases, the utility of these models can vary. The addition of semantic information is crucial to transforming mathematical models from esoteric to informative resources. 

We have developed a metadata specification framework to better enable the annotation of CellML models with metadata. The framework consists of a core specification describing, in general terms, how annotations should be attached using RDF/XML, and satellite specifications covering several domains of immediate interest, using elements from the Dublin Core, FOAF (Friend-Of-A-Friend), BIBO (Bibliographic... |
| Tipo: Poster |
Palavras-chave: Molecular Cell Biology; Bioinformatics; Data Standards. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6391/version/1 |
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| Jin Gu. |
| Transcription is the central process of gene regulation. In higher eukaryotes, the transcription of a gene is usually regulated by multiple cis-regulatory regions (CRRs). In different tissues, different transcription factors bind to their cis-regulatory motifs in these CRRs to drive tissue-specific expression patterns of their target genes. By combining the genome-wide gene expression data with the genomic sequence data, we proposed multiple-instance scoring (MIS) method to predict the tissue-specific motifs and the corresponding CRRs. The method is mainly based on the assumption that only a subset of CRRs of the expressed gene should function in the studied tissue. By testing on the simulated datasets and the fly muscle dataset, MIS can identify true... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Molecular Cell Biology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/4038/version/1 |
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| Edwin Wang. |
| We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer-associated genetically and epigenetically altered genes. We find that cancer mutating genes are enriched in positive signaling regulatory loops, whereas the cancer-associated methylating genes are enriched in negative signaling regulatory loops. We further characterized an overall picture of the cancer-signaling architectural and functional organization. From the network, we extracted an oncogene-signaling map, which contains 326 nodes, 892 links and the interconnections of mutated and methylated genes. The map can be decomposed into 12 topological regions or oncogene-signaling blocks,... |
| Tipo: Presentation |
Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2238/version/1 |
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| Martin A. Giese; Vittorio Caggiano; Falk Fleischer. |
| SUMMARY: The recognition of actions of conspecifics is crucial for survival and social interaction. Most current models on the recognition of transitive (goal-directed) actions rely on the hypothesized role of internal motor simulations for action recognition. However, these models do not specify how visual information can be processed by cortical mechanisms in order to be compared with such motor representations. This raises the question how such visual processing might be accomplished, and in how far motor processing is critical in order to account for the visual properties of action-selective neurons.
We present a neural model for the visual processing of transient actions that is consistent with physiological data and that accomplishes... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5862/version/1 |
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| Federico Esposti; Jacopo Lamanna; Maria Gabriella Signorini. |
| A lot of methods were created in last decade for the spatio-temporal analysis of multi-electrode array (MEA) neuronal data sets. All these methods were implemented starting from a channel to channel analysis, with a great computational effort and onerous spatial pattern recognition task. 
Our idea is to approach the MEA data collection from a different point of view, i.e. considering all channels simultaneously. We transform the 2D plus time MEA signal in a mono-dimensional plus time signal and elaborate it as a normal 1D signal, using the Space-Amplitude Transform method. 
This geometrical transformation is completely invertible and allows to employ very fast processing algorithms. 
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| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1306/version/1 |
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| Zheng Sixiang; Liu Feihu; Zhang Chaojun; Chen Zhilin; Ma Yuhua; Meng Pinghong; Zhao Yan. |
| Mitosis is nuclear division plus cytokinesis,and produces two identical daughter cells during prophase, prometaphase, metaphase, anaphase, and telophase. However, a new nucleus behavior in interspecific hybrid progenies of Lilium was observed in our experiment. Very unusual behaviors of nuclei surprisingly presented during the mitosis, such as sprouting or germination, tube-like elongation, penetrating cell membrane into a neighbor cell, the top of nuclei tube expanding, intruding and splitting of the tube-like nucleus, and micronucleus formation, and so on. Furthermore, the tetrad of meiosis was founded in mitosis of root.

Routine of the unusual nucleus behaviors observed in our experiment may be summarized as nucleus... |
| Tipo: Manuscript |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4631/version/1 |
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| UnCheol Lee; Seunghwan Kim; Gyu-Jeong Noh; Byung-Moon Choi. |
| As pointed out by William James, "the consciousness is a dynamic process, not a thing" , during which short term integration is succeeded by another differentiated neural state through the continual interplay between the environment, the body, and the brain itself. Thus, the dynamic structure underlying successive states of the brain is important for understanding human consciousness as a process. In order to investigate the dynamic property of human consciousness, we developed a new method to reconstruct a state space from electroencephalogram(EEG), in which a trajectory, reflecting states of consciousness, is constructed based on the global information integration of the brain. EEGs were obtained from 14 subjects received an intravenous... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1244/version/1 |
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| Patrick Connor; Thomas Trappenberg. |
| The striatum has long been implicated in reinforcement learning and has been suggested by several neurophysiological studies as the substrate for encoding the reward value of stimuli. Reward prediction error (RPE) has been used in several basal ganglia models as the underlying learning signal, which leads to Pavlovian conditioning abilities that can be simulated by the Rescorla-Wagner model.

Lateral inhibition between striatal projection neurons was once thought to have a winner-take-all function, useful in selecting between possible actions. However, it has been noted that the necessary reciprocal connections for this interpretation are too few, and the relative strength of these synaptic connections is weak. Still,... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5986/version/1 |
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| Registros recuperados: 3.453 | |
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